Pharmacologic Study of Oseltamivir in Healthy Volunteers

Inclusion Criteria: * healthy with no underlying chronic disease * normal baseline laboratory screening * no regular prescribed medication used in the past 30 days and no over-the-counter medication in the past week * agree to abstain from self-medication during the study * negative urine pregnancy test for females and agreement that they will not try to become pregnant until 1 month after the study is completed * only use non-hormonal methods of contraception for females * non-smoker for the last 30 days and for duration of the study * no consumption of alcohol for the last 30 days and for duration of the study * no use of recreational drugs for the last 30 days and for duration of the study Exclusion Criteria: * known hypersensitivity to oseltamivir and/or probenecid * Hepatitis B virus surface antigen positive * presence of intercurrent illness or any condition which in the judgement of the investigator would place the subject at undue risk or interfere with the results of the study