Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis

Laboratoires NEGMA96 enrolled

Overview

Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Osteoarthritis

Interventions

DiacerheinDRUG

Eligibility

Sex: ALLMin age: 45 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Painful osteoarthritis * Hydarthrosis (synovial effusion) Exclusion Criteria: * large effusion * severe pathologies * anti-osteoarthritic treatments

Locations (1)

Rheumatologic Institut of Montreal

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Synovial concentration of IL-1

Secondary Outcomes

Synovial concentration of IL-6

WOMAC

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.