Effect of nicotine patch as an adjutant for acute pain after surgery.
This is a dose finding trial for nicotine patches as analgesics. Doses used are 5mg/ 10mg/ 15mg or placebo. Primary outcome variable is reported pain score (VAS), secondary is morphine PCA utilization, nausea, sedation, and hemodynamic changes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
68
nicotine patch (0,5,10 or 15mg/day) applied to smokers
nicotine patch (0,5,10,or 15mg/day) applied to nonsmokers
placebo patch applied to smokers
Columbia University Irving Medical Center / New York Presbyterian
New York, New York, United States
Postoperative Pain Score One Hour After Surgery
Postoperative pain reported after the first hour using a standard numerical rating scale (NRS) with 0=no pain and 10=worst pain imaginable.
Time frame: 1 hour after surgery
Postoperative Pain Score Five Days After Surgery
Postoperative pain reported after five days using a standard numerical rating scale (NRS) with 0=no pain and 10=worst pain imaginable.
Time frame: 5 days
Nausea Assessment by Patient
Nausea scale range: 0=none and 10=the worst, ordinal.
Time frame: 1 hour after surgery
Pain Medication Used
Pain medication used after surgery in morphine equivalents
Time frame: 5 days
Systolic Blood Pressure
Systolic blood pressure reported in Millimeters of Mercury (mmHg)
Time frame: 1 hour after surgery
Diastolic Blood Pressure
Diastolic blood pressure reported in Millimeters of Mercury (mmHg)
Time frame: 1 hour after surgery
Heart Rate
Heart rate reported in Beats per minute (BPM)
Time frame: 1 hour after surgery
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placebo patch applied to nonsmokers