Safety Study of Specific Tumor Target Drug Plus Immune System Therapy in Patients With Kidney Cancer

Inclusion Criteria: * Pathological proof of clear cell carcinoma (or mixed tumors ≥ 75% clear cell component) * Evidence of measurable metastatic disease, no progression diseases or the patient's condition will not need radiotherapy in the next 4 weeks. * Previous definitive radiotherapy to 1 metastatic site is acceptable * At least 4 weeks have elapsed since radiation therapy * Patients must be free of serious co-morbidity and have a life expectancy of ≥24 weeks * Patients should have adequate physiologic reserves as evidence of adequate performance status, blood parameters, hepatic and kidney function, no evidence of active cardiac diseases and showing an acceptable function and adequate coagulation profile. Exclusion Criteria: * History of central nervous System metastases * Known HIV positive * Recent history of brain's vascular disease within 6 months; patients requiring regular antianginal therapy (coronary disease) or insufficient circulation in lower extremities are not eligible * Active autoimmune disease * Patients who have had steroid therapy in the past three weeks * Patients taking concurrent anticancer drugs * Biphosphonates (Zometa) are not allowed, unless started 4 weeks prior to participation in the study * Female patients pregnant or breast-feeding * The patient has an unstable medical condition, such as uncontrolled Diabetes mellitus or Hypertension; active infections requiring systemic antibiotics, antivirals, or antifungal; clinical evidence of cardiac or pulmonary dysfunction including, uncontrolled arrhythmias, unstable coagulation disorders; or recent myocardial infarction (within 6 months) * Any condition including abnormal laboratory results, that in the opinion of the investigator places the patient at an unacceptable risk if he/she participate in the study * Prior malignancy (within the last 3 years), except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer or other cancer for which the patient has been - free for at least 3 years * Uncontrolled Blood pressure \> 150/100 * Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study * Minor surgery 7 days before day 0 * Serious, non healing wound, ulcer, or bone fracture; and,inability to accomplish the treatment