Effect of Plant Sterols Esterified to Fish Oil Fatty Acids on Plasma Lipid Levels

Inclusion Criteria: * Male or female, \>18 years old and ≤ 70 years old, capable and willing to give written informed consent. * Subject must have hyperlipidemia at the screening visit and at the end of the run-in period, defined as: fasting plasma triglycerides \> 150 mg/dl and \< 500 mg/dl, LDL-cholesterol \> 130 mg/dl and \< 190 mg/dl. * Fasting plasma glucose (FPG) levels at the screening visit \< 110 mg/dl. * Female patient who is of reproductive potential agree to use acceptable methods of birth control * Female patient who is currently receiving hormone replacement therapy continuously 12 weeks before visit 1 (on stable dose) and will agree to do so during the study. Exclusion Criteria: * Receiving medications or supplements known to affect lipid metabolism. * Uncontrolled hypertension or thyroid disease. * Consume unusual diets - will be determined at the discretion of the investigator. * Gained or lost more than 3 kg during the run-in period. * Patient has history of malignancy ≤ 5 years. * Patients with clinical ischemic CV disease on treatment * Consume 200 grams fish x 2 a week. * Gastrointestinal disease or any disease that the investigator feels would compromise the patient safety or limit his/her successful participation to the study. * Patient has type 1 or type 2 diabetes mellitus. * Patient has uncontrolled endocrine or metabolic disease known to influence serum lipids or lipoproteins * Patient has had active peptic ulcer disease within 3 months of visit 1. * Woman patient is pregnant or breast-feeding or expecting to conceive during the study. * Patient has a history of hypersensitivity or allergy to fish, fish oil, corn oil or soy.