Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Radboud University Medical Center10 enrolled

Overview

Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. In the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Arrest Post-Anoxic Encephalopathy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 95 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients * GCS after return of circulation \< 7 * Induced mild hypothermia for 24 hours * primary rhythm ventricular fibrillation Exclusion Criteria: * Thrombolysis * Cardiogenic shock with expected survival \< 24 hrs * Pregnancy * No informed consent

Locations (1)

Radboud University Nijmegen Medical Centre

Nijmegen, Netherlands

RECRUITING

Central Contacts

Cornelia Hoedemaekers, MD PhD

CONTACT

00.31.24.3617273 C.Hoedemaekers@ic.umcn.nl

Data from ClinicalTrials.gov

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