Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome

Chonnam National University Hospital

Overview

To compare the therapeutic effect between autologous serum and umbilical cord serum eyedrops in the treatment of severe dry eye syndrome.

Ninety-two eyes of 48 patients with severe dry eye syndrome (34 eyes of 17 patients with Sjögren's syndrome and 58 eyes of 31 patients with non-Sjögren's syndrome) were treated with either 20% autologous serum (41 eyes of 21 patients) or umbilical cord serum eyedrops (51 eyes of 27 patients). Symptom scoring, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, tear clearance rate (TCR), corneal fluorescein staining, and conjunctival impression cytology were performed before and 1 month and 2 months after treatment.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Dry Eye Syndrome

Interventions

Umbilical cord serum eyedropsDRUG

Autologous serum eyedropsDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 61 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with severe dry eye syndrome who were refractory to conventional treatments and had symptoms of dry eye for more than 3 months * Low tear film break-up time (BUT, \< 5 sec) * Low Schirmer test (5 mm) * Positive fluorescein or rose bengal vital staining (≥ 3) Exclusion Criteria: * Active ocular infection or inflammation not associated with dry eye * Contact lens wear * Ocular allergy * Ocular surgery within the recent 3 months * Lid or lash abnormalities * Pregnant or lactating women

Locations (1)

Chonnam national university hospital

Gwangju, South Korea

Data from ClinicalTrials.gov

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