Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure

University of Aarhus10 enrolled

Overview

Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Addison Syndrome

Interventions

hydrocortisone substitution therapy versus withdrawalDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female adrenal failure * Age 18-50 * Written informed content Exclusion Criteria: * Diabetes mellitus * Cancer * Thromboembolic events * Pregnancy and lactation * Heart disease

Outcomes

Primary Outcomes

insulin sensitivity

local protein turnover

whole body protein turnover

glucose metabolism

serum metabolites

serum hormone levels

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.