Corticosteroids for the Prevention of Atrial Fibrillation After Cardiac Surgery

Kuopio University Hospital1 enrolled

Overview

Atrial fibrillation is the most common arrhythmia to occur after cardiac surgery. Inflammatory response may be one etiological factor. We hypothesized that intravenous corticosteroid administration after cardiac surgery prevents AF after cardiac surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Atrial Fibrillation

Interventions

intravenous hydrocortisoneDRUG

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled to undergo their first on-pump CABG, aortic valve replacement or combined aortic valve replacement and CABG were enrolled. Exclusion Criteria: * Previous episodes of AF or flutter * Uncontrolled diabetes mellitus * Systemic mycotic infection * Active tuberculosis * Cushing's syndrome * Psychotic mental disorder * Herpes Simplex keratitis * Serum creatinine exceeding 200 µg/ml * Patients were also excluded if they had a history of previous peptic ulcer or thrombophlebitis.

Outcomes

Primary Outcomes

Study couldn´t start due to investigator

Time frame: Study couldn´t start due to investigator

Secondary Outcomes

Study couldn´t start due to investigator

Time frame: Study couldn´t start due to investigator

Data from ClinicalTrials.gov

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