Safety and Acceptability of SPL7013 Gel (VivaGel™) in Sexually Active Women

Inclusion Criteria: * HIV-uninfected * General good health * Normal Pap result within 12 months prior to study entry * Predictable menstrual cycle with at least 21 days between menses * Sexually active * Willing to use effective methods of contraception for the duration of the study. More information on this criterion can be found in the protocol. * Willing to abstain from oral-vaginal and penile-anal intercourse for the duration of the study * Willing to not use other intravaginal products and/or devices for 72 hours prior to study entry through Week 3 * Agree to have partner use condoms provided by study for each act of intercourse during study participation * Willing to undergo colposcopy if determined necessary by investigator * Agree to not participate in other drug or device studies during study participation Exclusion Criteria: * History of adverse reaction to latex or to any component of the study products * History of male sex partner having an allergic reaction to latex * Any abnormal finding on physical or pelvic examination * Sexually transmitted infection (STI) or reproductive tract infection. More information on this criterion is available in the protocol. * Diagnosed with STI within 6 months prior to study entry * Use of oral and/or vaginal preparations of antibiotic or antifungal medications within 30 days prior to study entry * Gynecological surgical procedure within 90 days prior to study entry * Certain abnormal laboratory values. More information on this criterion is available in the protocol. * Received non-therapeutic intravenous drugs within 12 months prior to study entry * Any social or medical condition, that, in the opinion of the investigator, would interfere with the study * Pregnant of breastfeeding