The primary purpose of this research study is to test the ability of a proprietary cherry juice blend to be helpful in the treatment of osteoarthritis (OA) of the knee.
The primary objective is to determine if the proprietary tart cherry juice blend improves the pain and function in persons with knee osteoarthritis. A secondary objective is to ascertain if the blend lowers serum uric acid. This is a prospective double blind, placebo controlled cross-over study. The study will be performed in the Philadelphia VA Medical Center 1 South Rheumatology Clinic with patients meeting ACR criteria for Kellgren grade 2-3 knee osteoarthritis and 4-9 pain severity on a VAS. Fifty patients will be studied with each having 5 visits. Subjects will take either the proprietary cherry blend or placebo for 6 weeks and then switch. WOMAC pain and function will be the primary outcome with acetaminophen use, walking time and serum uric acid as secondary outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
59
2 bottles per day for 6 weeks, 1 in the morning and 1 in the evening
2 bottles per day for 6 weeks, 1 in the morning and 1 in the evening
VA Medical Center
Philadelphia, Pennsylvania, United States
Improvement in Western Ontario McMaster Osteoarthritis Index (WOMAC) Scores to be taken at Visits 2-5.
Time frame: Visit 3 (week 6-7), Visit 5 (week 13-14)
Determine if there is a decrease in amount of non-prescription pain medication taken and/or improvement in score on a timed walking test (Visits 2,3,4,5).
Time frame: Visit 3 (week 6-7), Visit 5 (week 13-14)
Determine if there is a decrease in serum uric acid levels. (Visits 1,3,5)
Time frame: Visit 3 (week 6-7), Visit 5 (week 13-14)
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