The purpose of this study is to evaluate the tolerability, pharmacokinetics, pharmacodynamics, and biologic activity of MM-093 in patients with moderate to severe uveitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
20
MERSI
Cambridge, Massachusetts, United States
To evaluate the safety and tolerability of MM-093, as compared to placebo, when administered as a monotherapy once a week for 24 weeks after discontinuing IMT therapy.
To evaluate the biological activity of MM-093, as compared to placebo, as defined by the proportion of patients who have a relapse in their uveitis after discontinuing IMT therapy.
To evaluate the time to relapse of uveitis after IMT therapy has been discontinued.
To evaluate the degree of IMT tapering before a recurrence of uveitis occurs.
To evaluate visual function as evidenced by visual acuity and by electroretinography.
To evaluate sub clinical inflammation as measured by fluorescein angiography.
To evaluate the formation of anti-MM-093 antibodies after MM-093 administration.
To evaluate the formation of anti-goat antibodies after MM-093 administration.
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