Symptomatic Efficacy of Diacerein in Knee Osteoarthritis

Laboratoires NEGMA500 enrolled

Overview

Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis. This study aims at confirming the efficacy of diacerhein in symptomatic knee osteoarthritis using known and validated criteria and according to the recommendations and guidelines for this kind of study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

500

Conditions

Knee Osteoarthritis

Interventions

DiacereinDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Painful primary osteoarthritis (VAS ≥ 40 mm) * Radiologically proven (Kellgren \& Lawrence grade I to III) * Requiring the prescription of a symptomatic treatment of pain Exclusion Criteria: * Severe associated diseases * Wash-out: AINS, Coxibs, Paracetamol, anti-osteoarthritic treatments, hyaluronic acid, knee tidal lavage * Other osteoarticular disease

Locations (1)

Chu Trousseau

Tours, France

Outcomes

Primary Outcomes

VAS on pain movement, WOMAC A 1.1 section

Secondary Outcomes

WOMAC : total, pain, physical function

Paracetamol consumption

Global assessment of the patient

Responder patients with OMERACT-OARSI criteria

Tolerance

Data from ClinicalTrials.gov

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