The purpose of this study is to assess the safety and tolerability of escalating doses of SNS-032, given in 3 weekly administrations per cycle and to identify a recommended Phase 2 dose.
Other objectives of this study include measuring pharmacokinetics (how long the drug can be measured in the body) and identifying potential biomarkers.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
21
Stage 1: Escalating doses of SNS-032 on days 1, 8 and 15 per 28 day cycle Stage 2: Same as stage 1 except SNS-032 administered at the maximum tolerated dose established in stage 1
City of Hope
Duarte, California, United States
Stanford Cancer Center
Stanford, California, United States
Winship Cancer Institute at Emory University
Atlanta, Georgia, United States
Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, United States
To assess the safety and tolerability of SNS-032
Time frame: 1 year
To characterize the pharmacokinetic profile of SNS-032
Time frame: 1 year
Identify a recommended Phase 2 dose and schedule of administration
Time frame: 1 year
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Hackensack University Medical Center at the Cancer Center
Hackensack, New Jersey, United States
MD Anderson Cancer Center, University of Texas
Houston, Texas, United States