Our hypothesis is that adding midazolam and/or fentanyl to propofol sedation for elective outpatient colonoscopy increases cognitive impairment at hospital discharge without improving intraoperative conditions or reducing intraoperative side-effects. 200 healthy patients aged 18 years or older will be randomised to receive propofol or propofol plus midazolam and/or fentanyl. Cognitive impairment will be tested at hospital discharge using Cogstate computerised testing software.
A great variety of drug combinations are administered to patients having elective outpatient colonoscopy. In addition, as patients are going home, some may have residual cognitive deficits that making leaving the hospital unsafe. This study aims to find drugs combinations that are associated with the least cognitive impairment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
200
All drugs administered in doses according to anaesthetists' discretion during sedation for colonoscopy
Royal Melbourne Hospital
Parkville, Victoria, Australia
Cognitive impairment at hospital discharge after elective outpatient colonoscopy
Time frame: Before discharge from daycare facility
Dreaming during sedation, intraoperative operating conditions and complications, satisfaction with care
Time frame: Before discharge from daycare facility
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