A Pharmacokinetic and Bioavailability Study of Mannitol for Inhalation Using Normal Subjects

Inclusion Criteria: * Subject has signed a written informed consent form. * Subject is a normal male volunteer between 18 and 65 years of age. * Subject is willing to comply with the procedures of the study and to remain in the clinical unit for the scheduled visits. * Subject is willing to abstain from chewing gum for the duration of the study. Exclusion Criteria: * Subject has asthma or other disease affecting the lungs or airways. * Subject has a history indicating possible airway hyperresponsiveness. * Subject is allergic to mannitol or gelatin or a known intolerance to intravenous mannitol. * Subject uses inhaled drugs (legal or illegal). * Subject uses oral bronchodilator drugs. * Subject has celiac disease, Crohn's disease or other disease affecting intestinal absorption. * Subject has renal impairment or other condition that would affect urine collection. * Subject's weight deviates by more than 15% from the ideal weight listed for his height in the Metropolitan Life table. * Subject is a smoker. * Subject has participated in another clinical trial within the past 30 days. * Subject has used chewing gum within the past 72 hours. * Subject needs to use bisphosphonates, non-steroidal anti-inflammatory agents, or other drugs known to affect intestinal permeability on a chronic basis. * Subject has used non-steroidal anti-inflammatory agents within the past 72 hours