Efficacy and Safety Study of Cetuximab or Cetuximab Plus Docetaxel to Treat Prostate Cancer Before Prostatectomy

Inclusion Criteria: * Histologic proof of prostatic adenocarcinoma without evidence of regional and/or distant metastasis, clinical stage T1c or T2a with high grade disease (Gleason's 8-10) on initial biopsy, or clinical stage T2b-T2c with Gleason's grade 7 or above with a PSA ≥ 10ng/ml, or clinical stage T3. * Recent (\< 6 weeks prior to study entry) negative bone scan and MRI of abdomen and pelvis. * Appropriate surgical candidate for radical prostatectomy and a performance status of \< 2 (Zubrod scale). * Patients should have adequate bone marrow function defined as an absolute peripheral granulocyte count \> 1,500 and platelet count of \> 100,000, adequate hepatic function with a bilirubin \< 1.5 mg % and SGPT \< 2.5x the upper limits of normal, adequate renal function defined as serum creatinine \< 1.5 x ULN. * Patients must have normal coagulation profile (PT, PTT) and no history of substantial non-iatrogenic bleeding diatheses. Use of anticoagulants is limited to local use only (for control of central line patency). * Patients must have no history of congestive heart failure or previous MI within the last 12 months. Exclusion Criteria: * Previous or current hormonal treatment, chemotherapy, radiation therapy, immunotherapy or other investigational status drug. * Unable to tolerate transrectal ultrasound. * Patients who are not appropriate surgical candidates for radical prostatectomy based on the evaluation of co-existent medical diseases and competing causes of death. Patients with uncontrolled cardiac, hepatic, renal or neurologic/psychiatric disorder are not eligible. Patients with uncontrolled and symptomatic orthostatic hypotension or uncontrolled hypertension are not eligible. * Patients who are HIV positive or have chronic hepatitis B or C infections are not eligible. * Patients on oral steroid medications are not eligible. * Patients with significant arteriosclerotic disease, as defined by a previous arterial bypass claudication limiting activity, or a history of cerebrovascular events within the last year (including TIA) are not eligible. * Prior severe infusion reaction to a monoclonal antibody.