Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer

Inclusion Criteria: 1. Patients must have stage IV, histologically confirmed diagnosis of Adenocarcinoma of the colon. 2. Patients must have bi-dimensionally measurable disease since the purpose of this study is to determine efficacy of treatment. 3. Patients must be previously untreated. 4. Patients must be over the age of 18 years. 5. Patients may not be pregnant. Patients of childbearing years must be using contraception. 6. Patients must have ECOG performance status of 0-1 or KPS of at least 70. 7. Patients must have life expectancy of ≥ two months. 8. Patients must have a white blood cell count of ≥1000/mm³ ANC \> 1.0, platelets \> 100,000/mm³. 9. Patients must have adequate renal function as documented by a serum creatinine of ≤ 1.5 mg/dl. 10. Patients must have a bilirubin of ≤ 1.5 mg/dl and an SGOT of ≤ three times normal for patients with no liver disease, and ≤ five times normal for those with liver metastases. 11. Patients must be informed of the investigational nature of the study and give written informed consent. 12. Patients must have indwelling central venous catheter or good peripheral intravenous catheter, preferably a port-a-cath. 13. Patients may have had prior surgery for their colorectal cancer. Patients must be at least 8 weeks beyond surgery and recovered from all effects of surgery. 14. Patients enrolled in this study may have a history of prior malignancy (5 years ago) provided that the patient is currently disease-free. Exclusion Criteria: 1. Patients who have had prior chemotherapy or radiation therapy for their colorectal cancer, with exception of adjuvant chemo/radiation therapy. 2. Patients receiving concomitant radiation, hormonal therapy, chemotherapy, or immunotherapy. 3. Patients receiving any investigational drug within 30 days prior to start of this study. 4. Patients with serious underlying medical illnesses (including Congestive Heart Failure New York Heart Association Functional Classification 2-4) or active infection. 5. Patients with central nervous system metastasis must have completed radiation prior to entry into this protocol. 6. Patients with psychiatric conditions or associated conditions which would make participating in this study dangerous to their health. 7. Patients with uncontrolled hypertension.