Phase 2a Randomized, Double-Blind Study of Oleoyl-Estrone in Male Morbidly Obese Adults

Inclusion Criteria: * Subject is willing and able to provide signed informed consent. * Subject is a male and is between 18-60 years of age. * Subject is obese as defined as a BMI of 40 - 55. * Subject is reasonably healthy and have a reasonably acceptable medical history * Subject has a stable weight for the past 30 days per subject report. * Subject who has at least one factor of the metabolic * Subject exhibits stable behavior patterns with regard to smoking and exercise * Subject can read, speak and write the English language and agrees to follow study procedures. Exclusion Criteria: * Subjects who have received any investigational medication within 3 months prior to administration of study drug * Subjects with confirmed positive results of UDS or Alcohol * Subjects who are unwilling to return to the clinical research center on specified days during the treatment periods. * Subjects who have taken exclusionary medication * Subjects with any clinically significant laboratory abnormality or illness which, in the opinion of the Investigator, would contraindicate study participation * Subjects who have a history of testing positive for Hepatitis B virus, Hepatitis C virus, or HIV. * Subject has been involved in a formal or informal (self-imposed) diet regimen within the last 30 days. * Subject has a confirmed diagnosis or history of cancer, with the exception of nonmelanoma skin cancer. * Subject is otherwise unsuitable for the study, in the opinion of the investigator.