Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques

Sheba Medical Center120 enrolled

Overview

Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives: "1" Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression. "2" Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques. "3" Explore the potential role of infection in atherogenesis.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Atherosclerosis Aortic Aneurysm Peripheral Vascular Diseases

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Evidence of symptomatic carotid stenosis exceeding 60%(TIAs or stroke within the last 6 months), and asymptomatic carotid artery stenosis (presenting with progressive carotid stenosis, exceeding 70%) * Abdominal aortic aneurysm, and aortic occlusive disease * Peripheral occlusive or aneurysmal disease Exclusion Criteria: * Non-compliant patients, incapable of granting approval by informed consent

Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes