Dose Finding of Quetiapine Fumarate 200mg vs 400mg in First Episode Psychosis

AstraZeneca150 enrolled

Overview

The purpose of this study is determine the minimal effective dose and the impact on: 1. treatment outcomes at 4, 12 and/or 48 weeks the treatment has required to treat patients experiencing the first psychotic episode 2. the final maintenance doses 3. the use of other medications 4. the amount of changes to other antipsychotic medication 5. the number of hospitalization days

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

150

Conditions

Psychosis

Interventions

Quetiapine FumarateDRUG

Eligibility

Sex: ALLMin age: 15 YearsMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients experiencing their first psychotic episode * Male or Female * Aged 15-25 Exclusion Criteria: * Previous treatment with antipsychotic medication (longer than 1 week) * History of a clinically significant physical illness * Organic disorder presenting with psychotic symptoms

Locations (1)

Research Sites

Melbourne, Australia

Outcomes

Primary Outcomes

Medication dose, Remission and response rate, exBPRSvs4, SANS, CGI - I, CGI - S, CDSS, GAF and QoL scale

Secondary Outcomes

SWN, UKU, illicit substance use, laboratory measures, altered drop-out rates

Data from ClinicalTrials.gov

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