Metabolic Modulation as Treatment in Acute Heart Failure

Phase 2TerminatedNCT00449423

University of Aarhus32 enrolled

Overview

The primary objective of this study is to evaluate whether metabolic modulation improves hemodynamics and outcome in acute heart failure

Acute heart failure is a serious disease that despite modern therapies carries a high mortality. Inotropic drugs improve patient status but yield a higher risk of death. Previous studies have shown that myocardial contractility improves when glucose fermentation is up regulated and decreases when Free Fatty Acids are high. In a placebo-controlled design we wish to shift myocardial substrate metabolism towards increased glucose uptake and utilization and measure hemodynamics and biochemical markers of metabolism and prognosis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Acute Heart Failure

Interventions

acipimoxDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute heart failure * NYHA class III - IV. * ejection fraction \<35 Exclusion Criteria: * Age \<18 år or \>85 år, * allergy * renal failure * recently developed brady- or tachy-arrythmias * Serious infection * Heart failure due to restrictive or hypertrophic cardiomyopathy or stenotic valvular heart disease * Recent Myocardial infarction (\<6 Weeks) * Pulmonary Wedge pressure \>30 mm Hg * diabetes mellitus treated with insulin * peptic ulcer * pregnancy

Locations (1)

Aarhus University Hospital, Skejby Sygehus, Department of Cardiology

Aarhus, Aarhus, Denmark

Outcomes

Primary Outcomes

Cardiac index

pulmonary Wedge Pressure

Ejection fraction

Secondary Outcomes

myocardial glucose- and Free Fatty Acid-extraction

cardiac output

Regional left ventricle function

outcome day 6 and 30

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.