Multidrug Resistance After Trabeculectomy With Mitomycin C

University of Cologne30 enrolled

Overview

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glaucoma Trabeculectomy

Eligibility

Sex: ALLMin age: 8 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with planned trabeculectomy for elevated eye pressure * one third of patients without previous trabeculectomy * two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C) Exclusion Criteria: * patients not requiring surgery * patients with planned surgery for elevated eye pressure other than trabeculectomy

Locations (1)

The University Hospital of Cologne

Cologne, Germany

Data from ClinicalTrials.gov

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