The purpose of this study was to demonstrate in adult patients a faster recovery from a neuromuscular block with 2.0 mg/kg Org 25969 (sugammadex) after rocuronium as compared to 50 ug/kg neostigmine after cisatracurium when administered at reappearance of T2
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
84
Subjects received a bolus dose of 0.6 mg/kg rocuronium. After the last dose of rocuronium, at reappearance of T2, a dose of 2.0 mg/kg Org 25969 was to be administered
Subjects received a bolus dose of 0.15 mg/kg cisatracurium. After the last dose of cisatracurium, at reappearance of T2, a dose of 50 ug/kg neostigmine was to be administered. In accordance to the labeling of neostigmine, a maximum of 5 mg neostigmine was to be administered
Time from start administration of Org 25969/neostigmine to recovery T4/T1 ratio to 0.9
Time frame: After surgery
Time from start administration of Org 25969/neostigmine to recovery T4/T1 ratio to 0.7 and 0.8
Time frame: After surgery
Assessment of clinical signs of recovery (level of consciousness, 5 sec head lift, and general muscle weakness)
Time frame: after surgery
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