Study Comparing the Safety and Tolerance of SMOFlipid 20% in Long-term Treatment With Parenteral Nutrition

Inclusion Criteria: * In- and out-patients in need of parenteral nutrition due to inability to sustain an adequate oral/enteral food intake for at least 4 weeks * Written consent from the subject Exclusion Criteria: * Known hypersensitivity to fish-, egg-, soy-, or peanut-protein or to any of the active substances or excipients * Known type IV hyperlipidemia, disturbances in lipid metabolism or hypertriglyceridemia * Severe liver insufficiency * Severe blood coagulation disorders * Subjects with chronic stable renal insufficiency defined as S-creatinine value of \> 25 mg/l (200 µmol/l) or receiving dialysis/hemofiltration therapy * General contraindications to infusion therapy: acute pulmonary oedema, hyperhydration * Unstable conditions * Unstable angina pectoris * Acute shock * Chemotherapy within 4 weeks before start of the trial * Chemotherapy during the trial * Subjects for whom the trial treatment is not appropriate * Female patients must be surgically sterile; or postmenopausal for at least two years; or if of childbearing potential must have a negative serum pregnancy test and must agree to maintain adequate birth control practice during the study. * Participation in another clinical study with an investigational drug or an investigational medical device within one month prior to start of study or during the study * Prior inclusion in the present study * Any other feature that in the opinion of the investigator should preclude study participation