A Study to Evaluate the Safety and Effectiveness of FK778 in Liver Transplant Patients

Inclusion Criteria: * Male or female patients at least 18 years of age and not older than 65 years. * Female patients of child bearing potential must have a negative serum pregnancy test prior to enrollment and must agree to practice effective birth control during the study. * Male patients must agree to practice effective birth control methods during the study. * Patient is a recipient of a primary whole cadaveric liver transplant Exclusion Criteria: * Patient has previously received or is receiving an organ transplant other than a liver. * Patient has received an ABO incompatible donor liver. * Patient or donor is known to be HIV positive. * Patient has a current malignancy or a history of malignancy (within the past 5 years), except non-metastatic basal or squamous cell carcinoma of the skin that has been treated successfully. * Patient is being transplanted for hepatic malignancy with a single nodule greater than 5.0 cm in diameter or 2 or more nodules with at least one \> 3.0 cm. * Patient has a serum creatinine \>175 µmol/L at baseline. Patient has uncontrolled concomitant infections and/or severe diarrhoea, vomiting, active upper gastro-intestinal tract malabsorption or an active peptic ulcer or any other unstable medical condition that could interfere with the study objectives. * Patient who is receiving or may require warfarin or fluvastatin during the study. * Patient is participating in another clinical trial and/or is taking or has been taking an investigational drug in the 28 days prior to transplant