Tight Glycemic Control in Acute Exacerbations of COPD

Soroka University Medical Center84 enrolled

Overview

Glucose control has been shown as an important and independent prognostic factor in several acute conditions in hospitalized patients, including Acute MI, stroke, cardiac surgery and in critical care units. Patients with acute exacerbation of COPD (AECOPD)and diabetes treated with insulin had a longer in-patient stay and more frequent isolation of Gram negative bacteria from sputum than those without diabetes.Hyperglycemia (\>11 mmol/l) on admission predicted failure of non-invasive ventilation and infectious pulmonary complications in patients admitted to the ICU with acute respiratory failure caused by severe AECOPD. The primary goal of this study is to test the hypothesis that in AECOPD, tight glycemic control during hospital stay will improve outcome of hospitalization. The secondary goal of this study is to test new ways in controlling patients in the internal medicine ward.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

COPD Hyperglycemia

Interventions

Eligibility

Sex: ALLMin age: 45 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * current or past smokers (at least 20 py) * patient with COPD be ATS criteria * hospitalized with acute exacerbation, 2/3 criteria:1- worsening of SOB 2-change in sputum volume 3- change in sputum color * signed informed concent Exclusion Criteria: * respiratory failure (pH\<7.35 ו Pco2\>60 ) * pneumonia * pneumothorax * bronchiectasis * lung collapse * congestive heart failure * lung cancer * suspected pulmonary emboli * immune deficiency (acquired 0r congenital) * cystic fibrosis * post lung implantation * asthma/ non smokers

Tight Glycemic Control in Acute Exacerbations of COPD

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes