Statin for Immunomudulation in Sepsis

Inclusion Criteria: * clinical diagnosis of several sepsis or shock septic * no more than twenty four hours than diagnosis Exclusion Criteria: * use of statins in the last thirty days * unequivocal indication for statin treatment * active treatment with imunosuppressors drugs * High risk of rhabdomyolysis: multiple trauma, crush injuries, baseline creatinine kinase \> three times upper limit of normal * diagnosis of AIDS * unable to receive enteral medications * pregnancy * expected survival of less than 48 hours