Sevoflurane-Remifentanil Anaesthesia. The Risk of Post Operative Nausea

Central Jutland Regional Hospital160 enrolled

Overview

The purpose of this study is to determine whether sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia concerning post- operative nausea and vomiting.

Propofol and sevoflurane anaesthesia are used world wide at the anaesthetists discretion. Propofol is superior to inhalational anaesthetics as anaesthesia for patients at risk of post operative nausea and vomiting (PONV) as PONV is diminished. However, when remifentanil is used as adjuvant to sevoflurane, the total dose of the latter is reduced. Therefore, we wanted to investigate if sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia with emphasis on nausea, vomiting and total PONV during 24 hours. In the post anaesthesia care unit (PACU) and in the surgical ward nausea was scored on a visual analogue score. Vomiting was registered.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

160

Conditions

Nausea Vomiting

Interventions

Sevoflurane-remifentanil anaesthesiaPROCEDURE

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Females younger than 50 years * ASA I-II * Scheduled to gynaecological laparotomies or laparoscopies Exclusion Criteria: * Medication known to act anti-emetic * ASA status greater than II * Malignant hyperthermia * Allergy to the drugs used.

Locations (1)

Viborg Hospital

Viborg, Denmark

Outcomes

Primary Outcomes

Nausea, incidence and intensity ( VAS score )in PACU and surgical ward

Vomiting, incidence in PACU and surgical ward

Total PONV after 24 hours

Data from ClinicalTrials.gov

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