Phase 1 Clinical Trial of Varenicline in Chinese Healthy Smoking Volunteers

Inclusion Criteria: * Healthy male and/or female Chinese subjects between the ages of 18 and 45 years, inclusive. * Body Mass Index (BMI) of approximately 19 to 24 kg/m2; and a total body weight ≥50 kg. * Individuals who have smoked an average of at least 10 cigarettes per day during the past year, with no period of abstinence greater than 3 months in the past year. Exclusion Criteria: * Heart rate\>100 bpm, QRS Interval\>120 msec, QTc Interval \>430 msec, PR Interval\>220 msec, or any other abnormalities observed on the Electrocardiogram. * Subjects with a sitting blood pressure of 140/90 mmHg or above at screening. * Subjects with evidence or history of clinically significant allergic, hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric or neurological disease, or any condition possibly affecting drug absorption.