The Safety and Tolerability of GW805858 in Healthy Volunteers and Mild Asthmatics

Inclusion Criteria: * Men or women of non-child bearing potential, aged between 18 and 60 years of age inclusive. * Body weight = 50 kg (110 lbs) for men and = 45 kg for women and Body Mass Index (BMI) within the range 19.0-30.0 kg/m2 inclusive. * The subject is a current non-smoker who has not used any tobacco products in the last year. * A signed and dated written informed consent is obtained for the subject. * The subject is able to understand and comply with protocol requirements and timetables, instructions and protocol-stated restrictions. * If asthmatic, the subject must be a clinically stable asthmatic. Exclusion Criteria: * The subject has a history of allergy to ingredients within the inhaler. * The subject has received an investigational drug or participated in any other research trial within 30 days, prior to the first dose of current study medication. * The subject has used prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 14 days prior to the first dose of study medication. * The subject has an average weekly alcohol intake of greater than 21 units if male or 14 units if female. * The subject has any history of breathing problems (e.g. history of asthmatic symptoms). * The subject is infected with the hepatitis B, hepatitis C, or HIV virus. * The subject has had a respiratory tract infection or worsening of asthma within 4 weeks of the start of the study. * The subject has a past or present disease, which as judged by the Investigator, may affect the outcome of this study. * The subject has a history of life-threatening asthma, defined as an asthma episode that required intubation and/or was associated with hypercapnea, respiratory arrest or hypoxia seizures. * The subject has taken inhaled, nasal or dermal steroids within 4 weeks or oral steroids within 8 weeks of the start of the study. * The subject is unable to abstain from other drugs that may interfere with the conduct of the study. * The subject has ongoing rhinitis that requires treatment.