Cancer Immunotherapy GSK1572932A as Adjuvant Therapy for Patients With Tumor-antigen-positive Non-Small Cell Lung Cancer

Inclusion Criteria: * Written informed consent obtained, * Aged 18 or more, * Pathologically proven stage IB, II or III NSCLC, * Tumor expresses MAGE-A3, * Free of distant metastasis, * For Cohort 1, all of the following: 1. Completely resected stage IB, II or IIIA NSCLC, 2. Anatomical tumor resection, involving at least a lobectomy, and nodal sampling as per center standard 3. ECOG performance status = 0 or 1 4. Due to receive adjuvant chemotherapy as permitted in the protocol 5. Not received, not receiving, and not due to receive adjuvant radiotherapy (except stage III patients) 6. First administration of chemotherapy can be scheduled within 4-12 weeks after surgery * For Cohort 2, all of the following: 1. Resected stage IB, II or IIIA NSCLC, 2. Anatomical tumor resection, involving at least a lobectomy, and nodal sampling as per center standard 3. ECOG PS = 0 or 1 4. Due to receive, or receiving, adjuvant chemotherapy as permitted in the protocol 5. Not received, not receiving, and not due to receive, adjuvant radiotherapy (except stage III patients) 6. First administration of ASCI treatment can be scheduled within 2-4 weeks after the last administration of chemotherapy 7. Received at least 2 cycles of standard chemotherapy before ASCI treatment is initiated, whereafter no further chemotherapy is planned * For Cohort 3, all of the following: 1. Resected stage IB, II or IIIA NSCLC 2. Anatomical tumor resection, involving at least a lobectomy, and nodal sampling as per center standard 3. ECOG PS = 0 or 1 or 2 4. Not received, not receiving, and not due to receive, adjuvant chemotherapy 5. Not received, not receiving, and not due to receive, adjuvant radiotherapy (this does not apply to patients in stage III) 6. First administration of ASCI treatment can be scheduled within 4-8 weeks after surgery * For Cohort 4, all of the following: 1. Unresectable stage III NSCLC 2. ECOG PS = 0 or 1 or 2 3. Due to receive, or receiving, chemo- and radiotherapy according to institution standard 4. Received at least 2 cycles of standard chemotherapy before the initiation of ASCI treatment, whereafter no further chemo-/radiotherapy is planned 5. Stable disease or objective response (confirmed by CT scan) after standard chemo-/radiotherapy 6. Administration of ASCI treatment can be scheduled within 2-6 weeks after the last administration of chemo-/radiotherapy * Laboratory criteria: adequate bone-marrow reserve, adequate renal function, adequate hepatic function. * For females: EITHER not of child-bearing potential, OR sexually abstinent, OR negative urine pregnancy test + use of adequate contraceptive precautions from 30 days before first study treatment till 2 months after completion of study treatment course * In the view of the investigator, the patient can and will comply with the requirements of the protocol Exclusion criteria: * Previous or concomitant other malignancies, except if effectively treated and considered by the investigator highly likely to have been cured * Pregnant or lactating * History of anaphylaxis or severe allergic reaction * Concurrent severe medical problems, unrelated to the malignancy, limiting full compliance with the study or exposing the patient to unacceptable risk * Psychiatric or addictive disorders compromising the ability to give informed consent, or to comply with the trial procedures * HIV-positive * Require treatment with systemic corticosteroids, or other immunosuppressive agents * Need home oxygenation * Received or plan to receive investigational or non-registered product other than the study medication from 30 days before first dose of study medication and during whole study period * History of chronic alcohol consumption and/or drug abuse