The purpose of this study is to determine the benefits, if any, of combination therapy with Lucentis plus reduced fluence photodynamic therapy with Visudyne.
The study will have two treatment groups. Each group will receive intravitreal injections (injection of medication in the jelly-like part of the back of the eye). One group (Group1) of approximately 15 patients will receive 0.5 mg of Lucentis™ followed by reduced fluence Photodynamic Therapy (PDT) with Visudyne ® 1-2 weeks later. The other group (Group 2) of approximately 15 patients will receive 0.5 mg of Lucentis™ followed by Photodynamic Therapy with Visudyne on the same day. patients will be assigned at random to receive one of the two treatments arms in the study. The dose received at the first injection will be the same dose received throughout the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
reduced fluence photodynamic therapy with visudyne
Lucentis intravitreal injection
Barnes Retina Institute
St Louis, Missouri, United States
RECRUITINGTo assess the safety of the combination therapy
Time frame: 12 months and 24 months
To assess efficacy of the two timing regimens
Time frame: 12 months and 24 months
To evaluate the number of Lucentis injections and the number of PDT treatments required during the study
Time frame: 12 months and 24 months
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