Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease.
This is a double-blind, placebo-controlled crossover study of adult asthmatics given minocycline 150 mg po BID or placebo as add-on therapy for eight weeks each. Each eight week arm is separated by a four week wash-out. Spirometry is performed at the baseline and end of each arm. Daily symptoms scores, peak flow rates, and oral steroid requirements are recorded. A standardized asthma quality of life symptoms assessment is made every four weeks (AQLQ, Juniper).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
20
addition of antibiotic minocycline as antiinflammatory agent in addition to standard of care regimen.
Addition of oral placebo capsule in addition to standard of care regimen
SUNY Downstate Medical Center
Brooklyn, New York, United States
Decrease in oral steroid therapy requirements.
Time frame: 8 weeks
improvement in symptoms scores
Asthma Quality of Lifes Scores (AQLQ)
Time frame: 8 weeks
improvement in spriometric parameters
improvement in spirometric parameters including FEV1, FVC, FEV1/FVC, FEF25-75
Time frame: 8 weeks
improvement in morning and evening peak flow
Time frame: 8 weeks
decrease in rescue inhaler usage
Time frame: 8 weeks
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