Low Dose Continuous Administration of the Progesterone Receptor Modulator VA2914

Inclusion Criteria: * women in good general health with regular, ovulatory menstrual cycles * age 18-35 * not pregnant * not sexually active or reliably use barrier methods of contraception * normal liver and renal functions and normal laboratory exams Exclusion Criteria: * pregnant or breastfeeding * oral contraception, IUD or other hormonal treatment * use of agents known to induce hepatic P450 * cardiovascular disorder * hepatic, renal, or gastrointestinal disorder * metrorrhagia * abnormal transvaginal ultrasound (at baseline) * history of abnormal endometrial biopsy, * cancer * depression * mental illness * epilepsy * migraines * abnormal Pap Smear requiring further exploratory examination * anovulatory cycle before treatment * extreme overweight or underweight (body mass index \< 16 ou \>28) * subjects unlikely to comply with the protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study * use of narcotics * more than 10 cigarettes per day, more than 2 glasses of wine/beer per day * surgical procedures planned in the 6 months following screening visit