Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women

Iran University of Medical Sciences42 enrolled

Overview

paraoxonase 1 is involved to prevent LDL and HDL oxidation,so increase of it's activity leads to lower risk of coronary heart disease.In postmenopausal women ,we have decrease of paraoxonase1 activity and soy proteins may increase paraoxonase1 activity

In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Postmenopausal Hyperlipidemia

Interventions

soy consumptionPROCEDURE

Eligibility

Sex: FEMALEMin age: 51 YearsMax age: 57 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Cessation of menes for more than 1 year, elevation for more than 1 year * Elevation of FSH level * Total cholesterol * Triglyceride more than 200 mg/dl Exclusion Criteria: * Chronic disease (heart disease, cancer, diabetes, hepatic, kidney and thyroid disease) * Antihypertensive drugs * Antibiotics * Lipid lowering drugs * Sex hormone treatment * Hysterectomy * Diet rich in soy protein

Outcomes

Primary Outcomes

decrease of LDL,increase of HDL,increase of paraoxonase 1

Data from ClinicalTrials.gov

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