Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)

Hannover Medical School30 enrolled

Overview

Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective properties. The purpose of the present study is to characterize the quality of HDL-cholesterol in patients with coronary artery disease and normal blood HDL-cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-cholesterol in these patients. Additionally, the researchers aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with coronary artery disease and the changes dependent on physical activity of patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Coronary Artery Disease

Interventions

physical exercise

Eligibility

Sex: ALLMin age: 21 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Coronary artery disease * Normal HDL-cholesterol levels in blood: * \> 40 mg/dl (1.03 mmol/L) in males * \> 50 mg/dl (1.29 mmol/L) in females Exclusion Criteria: * Type 1 or 2 diabetes mellitus * Acute coronary syndrome * Unstable angina pectoris * Myocardial infarction during the last 8 weeks * Therapy with niacin * Active infections * Ventricular arrhythmias * Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 95 mmHg * Cancer * Pregnant or lactating * Alcoholism

Outcomes

Primary Outcomes

vasculoprotective and regenerative functions of HDL-cholesterol before and after 8-weeks of exercise training

Secondary Outcomes

flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound