Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks

Assistance Publique Hopitaux De Marseille1 enrolled

Overview

Cluster headache is characterized by unilateral excruciating head pain and autonomic dysfunction. Hypothalamic overactivity was observed in nitrate-induced cluster-headache and in only one case of spontaneous cluster headache 'Sprenger et al, 2004). This prompted the application of hypothalamic deep brain stimulation. The aim of this data is to precise the localisation of the hypothalamic activation.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Cluster Headache

Interventions

position emission transaxial tomographyPROCEDURE

cerebral position emission transaxial tomography using 18Fluorodeoxyglucose

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * cluster headache in crisis * no serious illnesses in progress as cancer, autoimmune disease, liver disease * patient without chronic psychiatric disease excluding moderate and reactional depression * no demential disease * no anxious or depressive disease * no contraindication to PET scan (pregnancy and breast-feeding) * social security cover * written informed consent Exclusion Criteria: * No effective contraception taken * unable to realize a decubitus of 15 minutes long

Locations (1)

Pôle de Neurosciences Cliniques CHU Timone

Marseille, France

Outcomes

Primary Outcomes

To confirm the existence of a hypothalamic promoter at the origin of Spontaneous Cluster Headache Attacks

Time frame: 2 years

Data from ClinicalTrials.gov

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