RATIONALE: New ways to find out about hearing loss after treatment with chemotherapy may improve the ability to plan cancer treatment and may help patients live more comfortably. PURPOSE: This clinical trial is assessing ear damage in young cancer patients treated with cisplatin.
OBJECTIVES: * Determine the optimal criteria for determination of ototoxicity in younger cancer patients treated with cisplatin. * Determine the feasibility of including ultrahigh frequency and evoked otoacoustic emission testing as adjunctive measures of ototoxicity. * Determine the feasibility and necessity of central review of audiometry data. OUTLINE: This is a multicenter, prospective, cohort study. Patients undergo hearing tests (conventional, otoscopy, ultrahigh frequency, and otoacoustic emission testing) before the first course of planned cisplatin, before each subsequent course of cisplatin, and 4 weeks after the last dose of cisplatin. Patients who are scheduled to receive hematopoietic progenitor stem cell transplantation undergo hearing tests before the transplantation and 4 weeks after transplantation. PROJECTED ACCRUAL: A total of 282 patients will be accrued for this study.
Study Type
OBSERVATIONAL
Enrollment
301
Undergo hearing tests
Incidence of patients with ototoxicity according to Common Toxicity Criteria, American-Speech-Language-Hearing Association, and Brock's criteria
Time frame: Length of study
Proportion of patients who undergo assessments using ultrahigh frequency (UHF) and evoked otoacoustic emission (OAE) testing
Time frame: Length of study
Proportion of patients with complete standard audiometry data (excluding UHF and OAE evaluations)
Time frame: Length of Study
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