ADMA and Mechanical Ventilation in Preterm Infants

Amsterdam UMC, location VUmc35 enrolled

Overview

The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.

Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Premature Birth

Eligibility

Sex: ALLMax age: 32 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * Gestational age \< 32 weeks * Birth weight \< 1500 gram * Written informed consent of parents Exclusion Criteria: * Congenital abnormalities * Chromosomal abnormalities

Data from ClinicalTrials.gov

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