A Titration Study of a Glucagon-Like Peptide-1 (GLP-1) Analogue in Patients With Type 2 Diabetes Treated With Metformin.

Inclusion Criteria: * male,and post-menopausal or surgically sterilized female, patients, 18-75 years of age; * type 2 diabetes mellitus, with stable metformin treatment for \>=3 months; * HbA1c \>=7.0% and \<=9.5% at screening; * stable weight +/-10% for \>=3 months before screening. Exclusion Criteria: * type 1 diabetes mellitus; * clinically significant gastrointestinal disease; * treatment with any anti-hyperglycemic medication other than metformin monotherapy during last 3 months; * use of weight-lowering medications in the last 3 months; * uncontrolled hypertension; * previous exposure to GLP-1 or GLP-1 analogues.