Functional MRI of Cognitive Control in Autism

UMC Utrecht90 enrolled

Overview

This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Autism

Eligibility

Sex: ALLMin age: 6 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 6 - 12 years at inclusion Inclusion criteria for subjects with autism * DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview Inclusion criteria for controls * No DSM-IV (APA, 1994) diagnosis, according to DISC interview * No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF) * IQ \> 70 Exclusion Criteria: * Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system * Presence of metal objects in or around the body (pacemaker, dental braces) * History of or present neurological disorder

Functional MRI of Cognitive Control in Autism

Overview

Conditions

Eligibility

Locations (1)

Central Contacts