CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis

Technische Universität Dresden100 enrolled

Overview

Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that 1. patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) \> area of reduced cerebral blood volume (CBV)) represent a significant proportion (\> 20%)of acute stroke patients and therefore are an important target group for future interventional studies 2. patients with a "tissue window" suffer an unfavourable outcome (\> 50 % mRS =\>4 at 3 months)if the occluded artery was not recanalized.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Stroke

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ischemic anterior circulation stroke * last seen normal \< 12 hours * stroke severity =\> 3 on the National Institute of Health Stroke Scale * multimodal CT stroke protocol performed * informed consent obtained Exclusion Criteria: * premorbid modified Rankin Scale score \> 3 * contraindications to contrast media application * pregnancy or breast feeding * subacute stroke \> 50 % of MCA territory * CT evidence of non-vascular cause of stroke symptoms

Locations (1)

University of Dresden, Dept of Neurology

Dresden, Germany

CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes