Evaluation of Carboplatin Plus Gemcitabine Followed by Concomitant Chemoradiation for Non-resectable Stage III NSCLC

Inclusion Criteria: * cytological or histologically proven NSCLC * unresectable stage III NSCLC * presence of at least one measurable lesion (RECIST criteria) * adequate haematological, renal and hepatic function * adequate lung function reserve * good condition, weight loss \<10% over previous 6 months, life expectancy \> 3 months Exclusion Criteria: * previous chemotherapy for NSCLC * distant metastasis or a pleural or pericardial effusion * treatment for malignant disease in the past or serious concomitant medical or psychiatric disease * active uncontrolled infection at time of inclusion * interstitial lung disease * auto-immune systemic disease with potential involvement of the lungs * concomitant use of amiodarone