The purpose of the study is to help determine if either crystalloid solution or colloid solution is more advantageous as a resuscitative fluid in post-operative pediatric cardiac patients.
The study is designed to help detect if there is an advantage in giving one type of resuscitative fluid versus another in the setting of post-operative pediatric cardiac patients. The two types of fluid being compared are crystalloid solution (normal saline) and colloid solution (5% albumin). The primary outcome measurement will be how much volume of each type of fluid will be required in order to maintain hemodynamic stability as determined by mean arterial blood pressure within predetermined parameters. Other secondary outcomes will include determinations of lactate clearance, inotropic support requirements, urine output, peripheral and pulmonary edema that occurs post-operatively, and the over all costs for each fluid based on number of required boluses and number of hours on mechanical ventilation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
32
5% albumin in 10cc/kg aliquots for postoperative volume resuscitation
saline in 10cc/kg aliquots for postoperative volume resuscitation
The Monroe Carell, Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, United States
maintenance of hemodynamic stability according to an age specific, predetermined, minimal mean arterial blood pressure
Time frame: Throughout the post operative period
lactate clearance
Time frame: Throughout the post operative period
inotropic requirements
Time frame: throughout the post operative period
establishment of adequate urine output
Time frame: Throughout the post operative period
post-operative occurrence of edema (peripheral and pulmonary)
Time frame: Througout the post operative period
monitoring of cost difference as determined by total number of boluses, number of ventilator hours, and length of ICU stay
Time frame: Throughout the ICU stay
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