Evaluation of Safety and Efficacy of 17-Beta Estradiol in Treatment of Atrophic Vaginitis: An Extension Trial

Inclusion Criteria: * Generally healthy * Postmenopausal * Hysterectomized or non-hysterectomized * Moderate or severe vaginal dryness and soreness * Successful completion of the study VAG/PD/009/USA Exclusion Criteria: * Known, suspected, or past history of breast cancer * Known, suspected, or past history of hormone-dependent tumor * Genital bleeding of unknown etiology * Acute thrombophlebitis or thromboembolic disorders or a past history of these conditions, associated with previous estrogen use * Subjects who had adverse events during the final visit, or discontinued prematurely, or were noncompliant in VAG/PD/009/USA * Exposure to any investigational new drug (other than what was dispensed in VAG/PD/009/USA) within the previous 30 days