Effect of Flaxseed on Lipid Uptake and Appetite

University of Copenhagen18 enrolled

Overview

Randomized trial to test the effect of flaxseed fractions on appetite regulation and intestinal lipid absorption.

Randomized multiple crossover trial in 18 healthy males aged 18 to 40 years each are required to complete a total of five iso-caloric meal tests lasting approximately 8½ hours. Test meals will be given as breakfast meals, in which different fractions of flaxseeds are incorporated into baked products. Appetite will be registered using visual analogue scales during 7 hours after the test meal and a total of 10 blood samples will be drawn to evaluate TAG in chylomicrons, plasma LDL, HDL and total cholesterol, plasma TAG, insulin, glucose and appetite hormone levels. At the end of the test day an ad libitum meal will be served and food intake registered.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Obesity

Interventions

Whole flaxseeds, flaxseed mucilage, glucomannanDIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy males aged 18-40 years * Normal weight or moderately overweigh (BMI 25-30 kg/m2) Exclusion Criteria: * Blood drawing/donation less than six months prior to start of the study * Hemoglobin concentration \<8mmol/L * Chronic diseases (i.e. diabetes, CVD), hypertension, hyperlipidemia * Consumption of dietary supplements including vitamin tablets * Smoking * Excess physical activity (\>10h of intense physical activity per week) * Medicine use (not including occasional consumption of pain killers)

Locations (1)

Institute of Human Nutrition

Frederiksberg C, Denmark

Outcomes

Primary Outcomes

TAG in chylomicrons

serum TAG

HDL, LDL and total cholesterol

appetite scores

ad libium food intake

appetite hormone levels

Secondary Outcomes

free fatty acid profile

plasma glucose

plasma insulin

meal macronutrient composition

meal energy content

meal pleasantness

Data from ClinicalTrials.gov

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