Efficacy and Safety of 17-Beta Estradiol in Treatment of Atrophic Vaginitis

Inclusion Criteria: * Generally healthy * Postmenopausal * Hysterectomized or non-hysterectomized * Moderate or severe vaginal dryness and soreness Exclusion Criteria: * Known, suspected, or past history of breast cancer * Known, suspected, or past history of hormone-dependent tumor * Genital bleeding of unknown etiology * Acute thrombophlebitis or thromboembolic disorders or a past history of these conditions, associated with previous estrogen use * Vaginal infection * Use of exogenous corticosteroids or sex hormones within 8 weeks of starting active treatment in study * Use of vaginal, oral or vulvar homeopathic preparations within seven days of starting active treatment in study * History of treatment with diethylstilbestrol