HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1 Co-infected Persons

Inclusion Criteria: * Greater than 18 years old woman, * Documented HIV-1 seropositive, * CD4 count greater than 200, * Not on HIV antiretroviral therapy, * HSV-2 seropositive as determined by Focus EIA (IN \>3.5) * Not intending to move out of the area for the duration of study participation. * Willing and able to:provide independent written informed consent;undergo clinical evaluations;take study drug as directed;adhere to follow-up schedule. * Bacterial STDs (symptomatic STD syndromes or laboratory-confirmed asymptomatic gonorrhea and syphilis) are treated within two weeks of study enrollment and random assignment. Exclusion Criteria: Women who meet any of the following criteria are not eligible for this study: * Known history of adverse reaction to valacyclovir, acyclovir or famciclovir; * Planned open label use of acyclovir, valacyclovir, or famciclovir * Known medical history of seizures * Known renal failure, serum creatinine \>2.0mg/dl * Hematocrit \< 30 %