Efficacy of Artesunate + Amodiaquine Four Years After Its Introduction in Zanzibar

Inclusion Criteria: * Age below 60 months * Weight ≥5kg * No general danger signs or severe malaria present (see 4.4.2.1 \& 4.4.2.2) * History of fever within 24 hours OR axillary temperature ≥ 37.5Cº * No other cause of fever is detectable * No severe malnutrition * Presence of P. falciparum asexual parasite density between 2000- 200,000/ul * Guardian/Patient has understood the procedures of the study and is willing to participate * Patient able to come for stipulated follow up visits and has easy access to the Study Site Exclusion Criteria: * Not able to drink or breastfeed * Persistent Vomiting * Recent history of convulsions * Lethargic or unconscious * Unable to sit or stand (as appropriate for age) * History of allergy to test drugs * History of intake of any drugs other than paracetamol and aspirin within 3 days